The somatosensory system decodes a wide range of tactile stimuli and thus endows us with
a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback …

Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured
neurons and along nociceptive and descending modulatory pathways in the central nervous …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

The dorsal horn of the spinal cord is critical to processing distinct modalities of noxious and
innocuous sensation, but little is known of the neuronal subtypes involved, hampering efforts …

The spinal dorsal horn is a major site for the induction and maintenance of mechanical
allodynia, but the circuitry that underlies this clinically important form of pain remains …

The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …

The original formulation of Gate Control Theory (GCT) proposed that the perception of pain
produced by spinal cord signaling to the brain depends on a balance of activity generated in …

The prevalence and cost of chronic pain is a major physical and mental health care problem
in the United States today. As a result, there has been a recent explosion of research on …

Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists
long after the injury has subsided, and is characterized by spontaneous pain and …

Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …