Rehabilitative training in animal models of spinal cord injury

A Torres-Espín, E Beaudry, K Fenrich… - Journal of …, 2018 - liebertpub.com
Rehabilitative motor training is currently one of the most widely used approaches to promote
moderate recovery following injuries of the central nervous system. Such training is …

[HTML][HTML] Restoring the sense of touch using a sensorimotor demultiplexing neural interface

PD Ganzer, SC Colachis, MA Schwemmer… - Cell, 2020 - cell.com
Paralyzed muscles can be reanimated following spinal cord injury (SCI) using a brain-
computer interface (BCI) to enhance motor function alone. Importantly, the sense of touch is …

Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

PD Ganzer, MJ Darrow, EC Meyers, BR Solorzano… - Elife, 2018 - elifesciences.org
Recovery from serious neurological injury requires substantial rewiring of neural circuits.
Precisely-timed electrical stimulation could be used to restore corrective feedback …

Opportunities and challenges for develo** closed-loop bioelectronic medicines

PD Ganzer, G Sharma - Neural regeneration research, 2019 - journals.lww.com
The peripheral nervous system plays a major role in the maintenance of our physiology.
Several peripheral nerves intimately regulate the state of the brain, spinal cord, and visceral …

Fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression

A Zahrai, F Vahid-Ansari, M Daigle, PR Albert - Translational psychiatry, 2020 - nature.com
Chronic treatment with fluoxetine (FLX) is required for its antidepressant effects, but the role
of serotonin (5-HT) axonal plasticity in FLX action is unknown. To address this, we examined …

Vagus nerve stimulation paired with rehabilitative training enhances motor recovery after bilateral spinal cord injury to cervical forelimb motor pools

MJ Darrow, M Torres, MJ Sosa… - … and neural repair, 2020 - journals.sagepub.com
Closed-loop vagus nerve stimulation (VNS) paired with rehabilitative training has emerged
as a strategy to enhance recovery after neurological injury. Previous studies demonstrate …

Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats

A Manohar, G Foffani, PD Ganzer, JR Bethea… - Elife, 2017 - elifesciences.org
After paralyzing spinal cord injury the adult nervous system has little ability to 'heal'spinal
connections, and it is assumed to be unable to develop extra-spinal recovery strategies to …

Serotonin receptor and dendritic plasticity in the spinal cord mediated by chronic serotonergic pharmacotherapy combined with exercise following complete SCI in the …

PD Ganzer, CR Beringer, JS Shumsky… - Experimental …, 2018 - Elsevier
Severe spinal cord injury (SCI) damages descending motor and serotonin (5-HT) fiber
projections leading to paralysis and serotonin depletion. 5-HT receptors (5-HTRs) …

What is the functional relevance of reorganization in primary motor cortex after spinal cord injury?

MA Urbin, DA Royston, DJ Weber, ML Boninger… - Neurobiology of …, 2019 - Elsevier
Motor output maps within primary motor cortex are widely distributed and modified by motor
skill learning and neurological injury. Functions that these maps represent after spinal cord …

Exercise therapy guides cortical reorganization after midthoracic spinal contusion to enhance control of lower thoracic muscles, supporting functional recovery

B Nandakumar, GH Blumenthal, GD Disse… - Experimental …, 2023 - Elsevier
Postural control is critical for locomotion, allowing for gait changes, obstacle avoidance and
navigation of rough terrain. A major problem after spinal cord injury (SCI) is regaining the …