Mesenchymal stem cells: isolation, in vitro expansion and characterization

N Beyer Nardi, L da Silva Meirelles - Stem cells, 2006 - Springer
Mesenchymal stem cells (MSC), one type of adult stem cell, are easy to isolate, culture, and
manipulate in ex vivo culture. These cells have great plasticity and the potential for …

Concise review: multipotent mesenchymal stromal cells in blood

Q He, C Wan, G Li - Stem cells, 2007 - academic.oup.com
Peripheral blood-derived multipotent mesenchymal stromal cells circulate in low number.
They share, most although not all, of the surface markers with bone marrow-derived …

Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion

MA Baxter, RF Wynn, SN Jowitt, JE Wraith… - Stem …, 2004 - academic.oup.com
Human marrow stromal cells (MSCs) can be isolated from bone marrow and differentiate
into multiple tissues in vitro and in vivo. These properties make them promising tools in cell …

A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow

RF Wynn, CA Hart, C Corradi-Perini, L O'Neill… - Blood, 2004 - ashpublications.org
Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after
transplantation, important for the correction of conditions such as metabolic storage …

Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy

JL Spees, CA Gregory, H Singh, HA Tucker, A Peister… - Molecular Therapy, 2004 - cell.com
Adult stem cells from human bone marrow stroma, referred to as mesenchymal stem cells or
marrow stromal cells (hMSCs), are attractive candidates for clinical use. The optimal …

Mesenchymal stem cells derived from CD133‐positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity

T Tondreau, N Meuleman, A Delforge, M Dejeneffe… - Stem …, 2005 - academic.oup.com
In this study, we used a common procedure to assess the potential of mobilized peripheral
blood (MPB) and umbilical cord blood (UCB) as sources of mesenchymal stem cells (MSCs) …

[HTML][HTML] Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue …

A De Becker, P Van Hummelen, M Bakkus… - …, 2007 - haematologica.org
Abstract Background and Objectives Mesenchymal stem cells (MSC) are adult stem cells
that can be expanded many fold in vitro and have the therapeutic potential to restore the …

Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases

J Reiser, XY Zhang, CS Hemenway… - Expert opinion on …, 2005 - Taylor & Francis
The intriguing biology of stem cells and their vast clinical potential is emerging rapidly for
gene therapy. Bone marrow stem cells, including the pluripotent haematopoietic stem cells …

Musculoskeletal manifestations of Hurler syndrome: long-term follow-up after bone marrow transplantation

JS Weisstein, E Delgado, LS Steinbach… - Journal of Pediatric …, 2004 - journals.lww.com
Bone marrow transplantation (BMT) is effective in ameliorating many of the clinical
manifestations of Hurler syndrome. However, long-term data on the natural history of the …

Transduction of bone-marrow-derived mesenchymal stem cells by using lentivirus vectors pseudotyped with modified RD114 envelope glycoproteins

XY Zhang, VF La Russa, J Reiser - Journal of virology, 2004 - journals.asm.org
Bone-marrow-derived mesenchymal stem cells (MSCs) have attracted considerable
attention as tools for the systemic delivery of therapeutic proteins in vivo, and the ability to …