MicroRNAs in liver disease
G Szabo, S Bala - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …
increasing evidence suggests that they have a role in liver pathology. This Review …
Targeting molecular mediators of ferroptosis and oxidative stress for neurological disorders
J Li, B Jia, Y Cheng, Y Song, Q Li… - Oxidative Medicine and …, 2022 - Wiley Online Library
With the acceleration of population aging, nervous system diseases including Alzheimer's
disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression …
disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression …
Alteration of the micro RNA network during the progression of Alzheimer's disease
An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the
hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23 controls, showing …
hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23 controls, showing …
The relation of the brain-derived neurotrophic factor with microRNAs in neurodegenerative diseases and ischemic stroke
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth
factors that plays a crucial role in the development of the nervous system while supporting …
factors that plays a crucial role in the development of the nervous system while supporting …
Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of …
The discovery and reliable detection of markers for neurodegenerative diseases have been
complicated by the inaccessibility of the diseased tissue-such as the inability to biopsy or …
complicated by the inaccessibility of the diseased tissue-such as the inability to biopsy or …
Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?
Exosomes are small membranous vesicles secreted by a number of cell types including
neurons and can be isolated from conditioned cell media or bodily fluids such as urine and …
neurons and can be isolated from conditioned cell media or bodily fluids such as urine and …
miR-212 and miR-132 are downregulated in neurally derived plasma exosomes of Alzheimer's patients
It was recently discovered that brain cells release extracellular vesicles (EV) which can pass
from brain into blood. These findings raise the possibility that brain-derived EV's present in …
from brain into blood. These findings raise the possibility that brain-derived EV's present in …
MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior
L Allen, Y Dwivedi - Molecular psychiatry, 2020 - nature.com
Childhood environment can have a profound impact on brain structure and function.
Epigenetic mechanisms have been shown to play a critical role in adaptive and maladaptive …
Epigenetic mechanisms have been shown to play a critical role in adaptive and maladaptive …
Adult-specific functions of animal microRNAs
K Sun, EC Lai - Nature reviews genetics, 2013 - nature.com
Abstract MicroRNAs (miRNAs) are~ 22 nt RNAs that coordinate vast regulatory networks in
animals and thereby influence myriad processes. This Review examines evidence that …
animals and thereby influence myriad processes. This Review examines evidence that …
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo
PY Smith, J Hernandez-Rapp, F Jolivette… - Human molecular …, 2015 - academic.oup.com
Alzheimer's disease (AD) and related tauopathies comprise a large group of
neurodegenerative diseases associated with the pathological aggregation of tau protein …
neurodegenerative diseases associated with the pathological aggregation of tau protein …