Despite monumental advances in molecular technology to generate genome sequence data
at scale, there is still a considerable proportion of heritability in most complex diseases that …

Background: Polygenic risk scores (PRS) are linear combinations of genetic markers
weighted by effect size that are commonly used to predict disease risk. For complex …

Many human diseases can be attributed to genetic variations in the genome. Scientists have
been identifying genetic variants associated with disease risks using population-based data …

The opioid epidemic continues to contribute to loss of life through overdose and significant
social and economic burdens. Many individuals who develop problematic opioid use (POU) …

Understanding the intricate relationship between an individual's genetic variants
(genotypes) and their observable traits (phenotypes) is imperative for comprehending the …

Motivation The interaction between genetic variables is one of the major barriers to
characterizing the genetic architecture of complex traits. To consider epistasis, network …

This thesis presents novel methods for interpreting genetic data, with a specific emphasis on
the genetic architecture of complex diseases. Traditional approaches attempt to analyze …

Background The prevalence and consequences of problematic opioid use (POU) continue
to be serious societal issues. Of the 71,000 overdose deaths that occurred in the United …

Sinds de vervollediging van het Humane Genome Project in 2003-2005 zijn GWAS studies
een populair instrument geworden binnen de genetische epidemiologie. In navolging van …

Abstract GENOME-wide Association Studies (GWAS) are increasingly popular in screening
the genetic architecture of human genome. For a typical GWAS study, half a million genetic …