Recent progress of the genetics of amyotrophic lateral sclerosis and challenges of gene therapy
H Wang, LP Guan, M Deng - Frontiers in neuroscience, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of motor neurons in the brain and spinal cord. The causes of ALS are not fully …
degeneration of motor neurons in the brain and spinal cord. The causes of ALS are not fully …
Amyotrophic lateral sclerosis: molecular mechanisms, biomarkers, and therapeutic strategies
X Yang, Y Ji, W Wang, L Zhang, Z Chen, M Yu, Y Shen… - Antioxidants, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the progressive
loss of motor neurons, leading to a fatal paralysis. According to whether there is a family …
loss of motor neurons, leading to a fatal paralysis. According to whether there is a family …
Genetic epidemiology of amyotrophic lateral sclerosis in Cyprus: a population-based study
E Mitsi, C Votsi, P Koutsou, A Georghiou… - Scientific Reports, 2024 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating, uniformly lethal degenerative disease
of motor neurons, presenting with relentlessly progressive muscle atrophy and weakness …
of motor neurons, presenting with relentlessly progressive muscle atrophy and weakness …
Generation of an Open-access patient-derived iPSC biobank for amyotrophic lateral sclerosis disease modelling
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting
the upper and lower motor neurons, causing patients to lose control over voluntary …
the upper and lower motor neurons, causing patients to lose control over voluntary …
Identification of a pathogenic mutation in ARPP21 in patients with amyotrophic lateral sclerosis
Background and objective Between 5% and 10% of amyotrophic lateral sclerosis (ALS)
cases have a family history of the disease, 30% of which do not have an identifiable …
cases have a family history of the disease, 30% of which do not have an identifiable …
Clinical and Genetic Analysis of A Father-Son Duo with Monomelic Amyotrophy: Case Report
Monomelic Amyotrophy (MMA) is a rare neurological disorder restricted to one upper limb,
predominantly affecting young males with an unknown aetiopathogenesis. We report a …
predominantly affecting young males with an unknown aetiopathogenesis. We report a …
Genetic and Functional Analysis of Glycosyltransferase 8 Domain–Containing Protein 1 in Taiwanese Patients With Amyotrophic Lateral Sclerosis
PC Tsai, KY Jih, TY Shen, YH Liu, KP Lin… - Neurology …, 2021 - AAN Enterprises
Background and Objectives To investigate the frequency, spectrum, and molecular
functional effect of glycosyltransferase 8 domain-containing protein 1 (GLT8D1) variations in …
functional effect of glycosyltransferase 8 domain-containing protein 1 (GLT8D1) variations in …
[PDF][PDF] Comprehensive genetic analysis of a Hungarian amyotrophic lateral sclerosis cohort
ZF Nagy - core.ac.uk
Comprehensive genetic analysis of a Hungarian amyotrophic lateral sclerosis cohort Ph.D thesis
Zsófia Flóra Nagy MD Doctoral Page 1 - 1 - Comprehensive genetic analysis of a Hungarian …
Zsófia Flóra Nagy MD Doctoral Page 1 - 1 - Comprehensive genetic analysis of a Hungarian …
Amyotrophic lateral sclerosis
In this chapter, we will review those genes most strongly associated with classical
amyotrophic lateral sclerosis (ALS). We will not review the clinical features of this disorder in …
amyotrophic lateral sclerosis (ALS). We will not review the clinical features of this disorder in …
[CITATION][C] Highly efficient base editing in rabbit by using near-PAMless engineered CRISPR/Cas9 variants
Z Zhang, X Wu, J Yang, X Liu, R Liu, Y Song - Science China Life …, 2023 - Springer
Base editors can achieve targeted C-to-T and A-to-G conversion without the generation of
DNA double-strand breaks (DSBs) or the requirement of a donor template, showing the …
DNA double-strand breaks (DSBs) or the requirement of a donor template, showing the …