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Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world
JM Hagel, PJ Facchini - Plant and Cell Physiology, 2013 - academic.oup.com
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized
metabolites with a long history of investigation. Although the ecophysiological functions of …
metabolites with a long history of investigation. Although the ecophysiological functions of …
[HTML][HTML] Towards a molecular understanding of the biosynthesis of Amaryllidaceae alkaloids in support of their expanding medical use
The alkaloids characteristically produced by the subfamily Amaryllidoideae of the
Amaryllidaceae, bulbous plant species that include well know genera such as Narcissus …
Amaryllidaceae, bulbous plant species that include well know genera such as Narcissus …
Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy
The gateway to morphine biosynthesis in opium poppy (Papaver somniferum) is the
stereochemical inversion of (S)-reticuline since the enzyme yielding the first committed …
stereochemical inversion of (S)-reticuline since the enzyme yielding the first committed …
Catalyzing plant science research with RNA-seq
Next generation DNA sequencing technologies are driving increasingly rapid, affordable
and high resolution analyses of plant transcriptomes through sequencing of their associated …
and high resolution analyses of plant transcriptomes through sequencing of their associated …
Papaver somniferum L. taxonomy, uses and new insight in poppy alkaloid pathways
F Labanca, J Ovesna, L Milella - Phytochemistry reviews, 2018 - Springer
Since ancient times, opium poppy (Papaver somniferum L.) is known for its medicinal
properties, related to its secondary metabolite content. Its most important secondary …
properties, related to its secondary metabolite content. Its most important secondary …
Regulation of the alkaloid biosynthesis by mi RNA in opium poppy
Opium poppy (P apaver somniferum) is an important medicinal plant producing
benzylisoquinoline alkaloids (BIA). Micro RNA s (mi RNA s) are endogenous small RNA s …
benzylisoquinoline alkaloids (BIA). Micro RNA s (mi RNA s) are endogenous small RNA s …
A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis
X Chen, JM Hagel, L Chang, JE Tucker… - Nature chemical …, 2018 - nature.com
The ultimate step in the formation of thebaine, a pentacyclic opiate alkaloid readily
converted to the narcotic analgesics codeine and morphine in the opium poppy, has long …
converted to the narcotic analgesics codeine and morphine in the opium poppy, has long …
Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy
Q Li, S Ramasamy, P Singh, JM Hagel… - Nature …, 2020 - nature.com
Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically
and industrially important compounds, and are often clustered on chromosomes. Here, we …
and industrially important compounds, and are often clustered on chromosomes. Here, we …
Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation
Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …
Metabolic engineering for the production of plant isoquinoline alkaloids
A Diamond, I Desgagné‐Penix - Plant biotechnology journal, 2016 - Wiley Online Library
Several plant isoquinoline alkaloids (PIA s) possess powerful pharmaceutical and
biotechnological properties. Thus, PIA metabolism and its fascinating molecules, including …
biotechnological properties. Thus, PIA metabolism and its fascinating molecules, including …