Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world

JM Hagel, PJ Facchini - Plant and Cell Physiology, 2013 - academic.oup.com
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized
metabolites with a long history of investigation. Although the ecophysiological functions of …

[HTML][HTML] Towards a molecular understanding of the biosynthesis of Amaryllidaceae alkaloids in support of their expanding medical use

AM Takos, F Rook - International journal of molecular sciences, 2013 - mdpi.com
The alkaloids characteristically produced by the subfamily Amaryllidoideae of the
Amaryllidaceae, bulbous plant species that include well know genera such as Narcissus …

Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy

SC Farrow, JM Hagel, GAW Beaudoin… - Nature chemical …, 2015 - nature.com
The gateway to morphine biosynthesis in opium poppy (Papaver somniferum) is the
stereochemical inversion of (S)-reticuline since the enzyme yielding the first committed …

Catalyzing plant science research with RNA-seq

LBB Martin, Z Fei, JJ Giovannoni… - Frontiers in plant …, 2013 - frontiersin.org
Next generation DNA sequencing technologies are driving increasingly rapid, affordable
and high resolution analyses of plant transcriptomes through sequencing of their associated …

Papaver somniferum L. taxonomy, uses and new insight in poppy alkaloid pathways

F Labanca, J Ovesna, L Milella - Phytochemistry reviews, 2018 - Springer
Since ancient times, opium poppy (Papaver somniferum L.) is known for its medicinal
properties, related to its secondary metabolite content. Its most important secondary …

Regulation of the alkaloid biosynthesis by mi RNA in opium poppy

H Boke, E Ozhuner, M Turktas… - Plant biotechnology …, 2015 - Wiley Online Library
Opium poppy (P apaver somniferum) is an important medicinal plant producing
benzylisoquinoline alkaloids (BIA). Micro RNA s (mi RNA s) are endogenous small RNA s …

A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis

X Chen, JM Hagel, L Chang, JE Tucker… - Nature chemical …, 2018 - nature.com
The ultimate step in the formation of thebaine, a pentacyclic opiate alkaloid readily
converted to the narcotic analgesics codeine and morphine in the opium poppy, has long …

Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy

Q Li, S Ramasamy, P Singh, JM Hagel… - Nature …, 2020 - nature.com
Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically
and industrially important compounds, and are often clustered on chromosomes. Here, we …

Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation

N Ozber, SC Carr, JS Morris, S Liang… - Nature …, 2022 - nature.com
Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …

Metabolic engineering for the production of plant isoquinoline alkaloids

A Diamond, I Desgagné‐Penix - Plant biotechnology journal, 2016 - Wiley Online Library
Several plant isoquinoline alkaloids (PIA s) possess powerful pharmaceutical and
biotechnological properties. Thus, PIA metabolism and its fascinating molecules, including …