Controversies and priorities in amyotrophic lateral sclerosis
Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS)
cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial …
cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial …
Clinical measures of bulbar dysfunction in ALS
Bulbar impairment represents a hallmark feature of Amyotrophic Lateral Sclerosis (ALS) that
significantly impacts survival and quality of life. Speech and swallowing dysfunction are key …
significantly impacts survival and quality of life. Speech and swallowing dysfunction are key …
Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes
In the past two decades, structural and functional neuroimaging findings have greatly
modified longstanding notions regarding the pathophysiology of amyotrophic lateral …
modified longstanding notions regarding the pathophysiology of amyotrophic lateral …
Machine learning in amyotrophic lateral sclerosis: achievements, pitfalls, and future directions
V Grollemund, PF Pradat, G Querin, F Delbot… - Frontiers in …, 2019 - frontiersin.org
Background: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive
neurodegenerative condition with limited therapeutic options at present. Survival from …
neurodegenerative condition with limited therapeutic options at present. Survival from …
Adaptive functional reorganization in amyotrophic lateral sclerosis: coexisting degenerative and compensatory changes
M Abidi, G de Marco, A Couillandre… - European Journal of …, 2020 - Wiley Online Library
Background and purpose Considerable functional reorganization takes place in
amyotrophic lateral sclerosis (ALS) in face of relentless structural degeneration. This study …
amyotrophic lateral sclerosis (ALS) in face of relentless structural degeneration. This study …
Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis
Objective: We investigated a large sample of patients with amyotrophic lateral sclerosis
(ALS) at rest in order to assess the value of 18F-2-fluoro-2-deoxy-d-glucose (18F-FDG) PET …
(ALS) at rest in order to assess the value of 18F-2-fluoro-2-deoxy-d-glucose (18F-FDG) PET …
Patterned functional network disruption in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting motor function, with additional evidence of extensive nonmotor involvement …
affecting motor function, with additional evidence of extensive nonmotor involvement …
Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis
Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …
Hippocampal pathology in amyotrophic lateral sclerosis: selective vulnerability of subfields and their associated projections
Although hippocampal involvement in amyotrophic lateral sclerosis (ALS) has been
consistently highlighted by postmortem studies, memory impairment remains under …
consistently highlighted by postmortem studies, memory impairment remains under …
Multiparametric MRI study of ALS stratified for the C9orf72 genotype
Objective: To describe the patterns of cortical and subcortical changes in amyotrophic lateral
sclerosis (ALS) stratified for the C9orf72 genotype. Methods: A prospective, single-center …
sclerosis (ALS) stratified for the C9orf72 genotype. Methods: A prospective, single-center …