Although Babesia represents an important worldwide veterinary threat and an emerging risk
to humans, this parasite has been poorly studied as compared to Plasmodium, its malaria …

Plasmodium vivax is the most widespread human malaria parasite, in part because it can
form latent liver stages known as hypnozoites after transmission by female anopheline …

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …

Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target
proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional …

Plasmodium sporozoites that are transmitted by blood-feeding female Anopheles
mosquitoes invade hepatocytes for an initial round of intracellular replication, leading to the …

New therapeutics are necessary for preventing Plasmodium vivax malaria due to easy
transmissibility and dormancy in the liver that increases the clinical burden due to recurrent …

In malaria parasites, although post-translational modification of proteins with N-. O-, and C-
glycosidic bond-linked glycans is limited, it is confined to relatively fewer proteins in which …

Background The circumsporozoite protein (CSP) of Plasmodium is a key surface antigen
that induces antibodies and T-cells, conferring immune protection in animal models and …

The O-fucosylation of the thrombospondin type I repeat (TSR) domain is important for TSR-
containing proteins' optimal folding and stability. However, the importance of Plasmodium O …

Tryptophan C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR)
domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 …