Monobodies as tool biologics for accelerating target validation and druggable site discovery
Despite increased investment and technological advancement, new drug approvals have
not proportionally increased. Low drug approval rates, particularly for new targets, are linked …
not proportionally increased. Low drug approval rates, particularly for new targets, are linked …
BindCraft: one-shot design of functional protein binders
Protein–protein interactions (PPIs) are at the core of all key biological processes. However,
the complexity of the structural features that determine PPIs makes their design challenging …
the complexity of the structural features that determine PPIs makes their design challenging …
Molecular architectures of centrosomes in C. elegans embryos visualized by cryo-electron tomography
F Tollervey, MU Rios, E Zagoriy, JB Woodruff… - Developmental Cell, 2024 - cell.com
Centrosomes organize microtubules that are essential for mitotic divisions in animal cells.
They consist of centrioles surrounded by pericentriolar material (PCM). Questions related to …
They consist of centrioles surrounded by pericentriolar material (PCM). Questions related to …
Spatiotemporal resolution in high-speed atomic force microscopy for studying biological macromolecules in action
K Umeda, SJ McArthur, N Kodera - Microscopy, 2023 - academic.oup.com
High-speed atomic force microscopy (HS-AFM) is a unique approach that allows direct real-
time visualization of biological macromolecules in action under near-physiological …
time visualization of biological macromolecules in action under near-physiological …
Self-assembled nanomicelles of affibody-drug conjugate with excellent therapeutic property to cure ovary and breast cancers
Affibody molecules are small non-immunoglobulin affinity proteins, which can precisely
target to some cancer cells with specific overexpressed molecular signatures. However, the …
target to some cancer cells with specific overexpressed molecular signatures. However, the …
[HTML][HTML] Native molecular architectures of centrosomes in C. elegans embryos
F Tollervey, MU Rios, E Zagoriy, JB Woodruff… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Centrosomes organize microtubules that are essential for mitotic divisions in animal cells.
They consist of centrioles surrounded by Pericentriolar Material (PCM). Questions related to …
They consist of centrioles surrounded by Pericentriolar Material (PCM). Questions related to …
Advancements in Nanomechanical Characterization and Biomolecular Imaging with Atomic force Microscopy
V Cencen - 2024 - infoscience.epfl.ch
Atomic force microscopy (AFM) is a widely used imaging tool for obtaining a variety of
information for a range of samples. Although it was initially intended to serve as a method of …
information for a range of samples. Although it was initially intended to serve as a method of …