Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress
Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …
over 30 million people globally. Currently, no effective treatment is available due to multiple …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
Preclinical models for Alzheimer's disease: past, present, and future approaches
A robust preclinical disease model is a primary requirement to understand the underlying
mechanisms, signaling pathways, and drug screening for human diseases. Although various …
mechanisms, signaling pathways, and drug screening for human diseases. Although various …
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease
Alzheimer's disease (AD) is a progressive brain disorder associated with slow loss of brain
functions leading to memory failure and modest changes in behavior. The multifactorial …
functions leading to memory failure and modest changes in behavior. The multifactorial …
[HTML][HTML] Indole-3 carbinol and diindolylmethane mitigated β-amyloid-induced neurotoxicity and acetylcholinesterase enzyme activity: in silico, in vitro, and network …
Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by
beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities …
beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities …
Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer's Disease
Alzheimer's disease (AD), a multifactorial complex neural disorder, is categorized with
progressive memory loss and cognitive impairment as main clinical features. The multitarget …
progressive memory loss and cognitive impairment as main clinical features. The multitarget …
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease
The multitarget-directed strategy offers an effective and promising paradigm to treat the
complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of …
complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of …
Discovery of multi-target directed 3-OH pyrrolidine derivatives through a semisynthetic approach from alkaloid vasicine for the treatment of Alzheimer's disease
Vasicine is a pyrroloquinazoline alkaloid, which has been isolated from the plant Adhatoda
vasica. Naturally inspired semi-synthetic transformations were prepared using vasicine as a …
vasica. Naturally inspired semi-synthetic transformations were prepared using vasicine as a …
Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal …
Alzheimer's disease (AD) is multifactorial, progressive neurodegeneration with impaired
behavioural and cognitive functions. The multitarget-directed ligand (MTDL) strategies are …
behavioural and cognitive functions. The multitarget-directed ligand (MTDL) strategies are …
4, 6-Diphenylpyrimidine derivatives as dual inhibitors of monoamine oxidase and acetylcholinesterase for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder with multifactorial pathogenesis.
Monoamine oxidase (MAO) and acetylcholinesterase enzymes (AChE) are potential targets …
Monoamine oxidase (MAO) and acetylcholinesterase enzymes (AChE) are potential targets …