Pan-assay interference compounds (PAINS) are promiscuous compound classes that
produce false positive hits in high-throughput screenings. Yet, the mechanisms of PAINS …

We used a structure-based drug discovery approach to identify novel inhibitors of human
dihydroorotate dehydrogenase (DHODH), which is a therapeutic target for treating cancer …

Background: Diagnosed invasive breast carcinomas in African American patients are more
aggressive compared with those in Caucasian patients and diagnosed at later stages of the …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) requires
finding new drugs or repurposing drugs for clinical use. Molecular docking belongs to …

Phenylalanine hydroxylase (PAH) deficiency (PAHD) is an autosomal recessive disorder
that causes severe injury to the nervous system, the treatment of which mainly depends on …