Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …

3D cryo-electron microscopy (cryo-EM) is an expanding structural biology technique that has
recently undergone a quantum leap progression in its achievable resolution and its …

The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a
membrane-embedded protease that controls a number of important cellular functions …

The amyloid hypothesis has yielded a series of well-validated candidate drug targets with
potential for the treatment of Alzheimer disease (AD). Three proteases that are involved in …

Presenilins were first discovered as sites of missense mutations responsible for early-onset
Alzheimer disease (AD). The encoded multipass membrane proteins were subsequently …

Amyloid β protein (Aβ), a pathogenic molecule associated with Alzheimer's disease, is
produced by γ-secretase, which cleaves the β-carboxyl terminal fragment (βCTF) of β …

Presenilin mutations are the main cause of familial Alzheimer disease. From a genetic point
of view, these mutations seem to result in a gain of toxic function; however, biochemically …

The presenilin-containing γ-secretase complex is an unusual membrane-embedded
protease that processes a wide variety of integral membrane proteins, clearing protein stubs …

One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …

The Notch signaling pathway constitutes an ancient and conserved mechanism for cell-cell
communication in metazoan organisms, and has a central role both in development and in …