SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

Household secondary attack rates of SARS-CoV-2 by variant and vaccination status: an updated systematic review and meta-analysis

ZJ Madewell, Y Yang, IM Longini… - JAMA network …, 2022 - jamanetwork.com
Importance An overall household secondary attack rate (SAR) of 18.9%(95% CI, 16.2%-
22.0%) through June 17, 2021 was previously reported for SARS-CoV-2. Emerging variants …

Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines

JE Bowen, A Addetia, HV Dang, C Stewart, JT Brown… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern comprises several sublineages, with BA. 2 and BA. 2.12. 1 having replaced the …

Less neutralization evasion of SARS-CoV-2 BA. 2.86 than XBB sublineages and CH. 1.1

Y Hu, J Zou, C Kurhade, X Deng… - Emerging microbes & …, 2023 - Taylor & Francis
ABSTRACT The highly mutated BA. 2.86, with over 30 spike protein mutations in
comparison to Omicron BA. 2 and XBB. 1.5 variants, has raised concerns about its potential …

Assessing changes in incubation period, serial interval, and generation time of SARS-CoV-2 variants of concern: a systematic review and meta-analysis

X Xu, Y Wu, AG Kummer, Y Zhao, Z Hu, Y Wang, H Liu… - BMC medicine, 2023 - Springer
Background After the first COVID-19 wave caused by the ancestral lineage, the pandemic
has been fueled from the continuous emergence of new SARS-CoV-2 variants …

[HTML][HTML] Vaccine effectiveness against transmission of alpha, delta and omicron SARS-COV-2-infection, Belgian contact tracing, 2021–2022

T Braeye, L Catteau, R Brondeel, JAF van Loenhout… - Vaccine, 2023 - Elsevier
Objectives Vaccine effectiveness against transmission (VET) of SARS-CoV-2-infection can
be estimated from secondary attack rates observed during contact tracing. We estimated …

[HTML][HTML] Breakthrough infections after COVID-19 vaccination: Insights, perspectives and challenges

E Amanatidou, A Gkiouliava, E Pella, M Serafidi… - Metabolism open, 2022 - Elsevier
Vaccination programs against SARS-CoV-2 constitute the mainstay of public health
interventions against the global COVID-19 pandemic. Currently available vaccines have …

Effectiveness of the pre-Omicron COVID-19 vaccines against Omicron in reducing infection, hospitalization, severity, and mortality compared to Delta and other …

P Paul, A El-Naas, O Hamad, MA Salameh… - Human Vaccines & …, 2023 - Taylor & Francis
Despite widespread mass rollout programs, the rapid spread of the SARS-CoV-2 Omicron
variant called into question the effectiveness of the existing vaccines against infection …

[PDF][PDF] COVID‐19: Omicron–the latest, the least virulent, but probably not the last variant of concern of SARS‐CoV‐2

H Brüssow - Microbial Biotechnology, 2022 - Wiley Online Library
The Omicron variant rapidly became the dominant SARS‐CoV‐2 strain in South Africa and
elsewhere. This review explores whether this rise was due to an increased transmission of …

Heterogeneous infectivity and pathogenesis of SARS-CoV-2 variants beta, delta and omicron in transgenic K18-hACE2 and wildtype mice

F Tarrés-Freixas, B Trinité, A Pons-Grífols… - Frontiers in …, 2022 - frontiersin.org
The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced
transmissibility, more severity and/or immune evasion; however, the pathogenesis of these …