Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of
white blood cells of the immune system and play critical roles in immune cell signaling …

Cell-cell interactions and cell adhesion are key mediators of cancer progression and
facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many …

Siglecs are a family of sialic acid–binding receptors expressed by cells of the immune
system and a few other cell types capable of modulating immune cell functions upon …

First-generation immune checkpoint inhibitors, including anti–CTLA-4 and anti–programmed
death 1 (anti–PD-1) antibodies, have led to major clinical progress, yet resistance frequently …

The mammalian immune system evolved to tightly regulate the elimination of pathogenic
microbes and neoplastic transformed cells while tolerating our own healthy cells. Here, we …

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that
recognize sialoglycans–sialic acid containing glycans that are abundantly present on cell …

The glycan structures of the receptor binding domain of the SARS‐CoV2 spike glycoprotein
expressed in human HEK293F cells have been studied by using NMR. The different …

Glycans–simple or complex carbohydrates–play key roles as recognition determinants and
modulators of numerous physiological and pathological processes. Thus, many …

A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell
surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan …

CD22 maintains a baseline level of B-cell inhibition to keep humoral immunity in check. As a
B-cell-restricted antigen, CD22 is targeted in therapies against dysregulated B cells that …