The ribosome has recently transitioned from being viewed as a passive, indiscriminate
machine to a more dynamic macromolecular complex with specialized roles in the cell …

Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than intrinsic regulatory capacity in mRNA translation. However, emerging studies reveal …

Regulation of mRNA translation offers the opportunity to diversify the expression and
abundance of proteins made from individual gene products in cells, tissues and organisms …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal …

Ribosomes are essential components of the protein synthesis machinery. The process of
ribosome biogenesis is well organized and tightly regulated. Recent studies have shown …

Ribosomal biogenesis is tightly associated with cellular activities, such as growth,
proliferation, and cell cycle progression. Perturbations in ribosomal biogenesis can initiate …

Osteoporosis is a complex human disease that results in increased susceptibility to fragility
fractures. It can be phenotypically characterized using several traits, including bone mineral …

While transcription as regulated by histones and their post-translational modifications has
been well described, the function of histone variants in this process remains poorly …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR), with approximately 90% of patients harboring at least one copy of the disease …