Amelogenesis: Transformation of a protein-mineral matrix into tooth enamel

M Pandya, TGH Diekwisch - Journal of structural biology, 2021 - Elsevier
During enamel formation, the organic enamel protein matrix interacts with calcium
phosphate minerals to form elongated, parallel, and bundled enamel apatite crystals of …

Controlling enamel remineralization by amyloid‐like amelogenin mimics

D Wang, J Deng, X Deng, C Fang, X Zhang… - Advanced …, 2020 - Wiley Online Library
In situ regeneration of the enamel‐like structure of hydroxyapatite (HAp) crystals under oral
conditions is significant for dental caries treatment. However, it is still a challenge for dentists …

Controls of nature: Secondary, tertiary, and quaternary structure of the enamel protein amelogenin in solution and on hydroxyapatite

WJ Shaw, BJ Tarasevich, GW Buchko… - Journal of structural …, 2020 - Elsevier
Amelogenin, a protein critical to enamel formation, is presented as a model for
understanding how the structure of biomineralization proteins orchestrate biomineral …

Peptide-based bioinspired approach to regrowing multilayered aprismatic enamel

K Mukherjee, Q Ruan, S Nutt, J Tao, JJ De Yoreo… - Acs Omega, 2018 - ACS Publications
The gradual discovery of functional domains in native enamel matrix proteins has enabled
the design of smart bioinspired peptides for tooth enamel mimetics and repair. In this study …

Leucine-rich amelogenin peptides regulate mineralization in vitro

E Le Norcy, SY Kwak… - Journal of dental …, 2011 - journals.sagepub.com
Amelogenin's capacity to regulate enamel formation is related to its conserved N-and C-
terminal domains, its ability to self-assemble, and its ability to stabilize amorphous calcium …

Cementomimetics—constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides

M Gungormus, EE Oren, JA Horst, H Fong… - International journal of …, 2012 - nature.com
Cementum is the outer-, mineralized-tissue covering the tooth root and an essential part of
the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease …

Ultrastructure of early amelogenesis in wild‐type, Amelx‐/‐, and Enam‐/‐ mice: enamel ribbon initiation on dentin mineral and ribbon orientation by ameloblasts

CE Smith, Y Hu, JCC Hu… - Molecular Genetics & …, 2016 - Wiley Online Library
Introduction Dental enamel is comprised of highly organized, oriented apatite crystals, but
how they form is unclear. Methods We used focused ion beam (FIB) scanning electron …

Remineralization efficacy of an amelogenin-based synthetic peptide on carious lesions

J Chu, X Feng, H Guo, T Zhang, H Zhao… - Frontiers in …, 2018 - frontiersin.org
Objective: The aim of this study was to evaluate the remineralization efficacy of an
amelogenin-based peptide on initial enamel carious lesions in vitro. Furthermore, we …

Meeting report: a hard look at the state of enamel research

OD Klein, O Duverger, W Shaw, RS Lacruz… - International journal of …, 2017 - nature.com
Abstract The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines (ENAMEL)
Development workshop was held on 23 June 2017 at the Bethesda headquarters of the …

Enamel ribbons, surface nodules, and octacalcium phosphate in C57BL/6 Amelx−/− mice and Amelx+/− lyonization

Y Hu, CE Smith, Z Cai, LAJ Donnelly… - … Genetics & Genomic …, 2016 - Wiley Online Library
Background Amelogenin is required for normal enamel formation and is the most abundant
protein in develo** enamel. Methods Amelx+/+, Amelx+/−, and Amelx−/− molars and …