Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

Native mass spectrometry (nMS) is well established as a biophysical technique for
characterising biomolecules and their interactions with endogenous or investigational small …

Molecular dynamics simulations of unprecedented duration now can provide new insights
into biomolecular mechanisms. Analysis of a 1-ms molecular dynamics simulation of the …

A previously studied congeneric series of thermolysin inhibitors addressing the solvent-
accessible S2′ pocket with different hydrophobic substituents showed modulations of the …

Lifetime prolongation for hydrophobic drug carriers has been the focus of interest for many
years. Poloxamer (Pluronic F68, PF68) has been employed in this study for modifying the …

Drug discovery of small molecules from target selection through to clinical evaluation is a
very complex, challenging but rewarding area of drug discovery. There are many obstacles …

Protein-templated fragment ligations have been established as a powerful method for the
assembly and detection of optimized protein ligands. Initially developed for reversible …

Biotechnology has given rise to a broad range of biotherapies or biologics, including
biomolecular drugs, vaccines, cell or gene therapies. This chapter focuses on biomolecular …

The d-aspartate ligase of Enterococcus faecium (Asl fm) is an attractive target for the
development of narrow-spectrum antibacterial agents that are active against multidrug …

The 4-aminoantipyrine derivatives comprising both N-and O-donor modes generate novel
coordination assemblies which tend to exhibit anti-tumor activities. Crystallographic study of …