Emerging role of metabolomics in ovarian cancer diagnosis

A Saorin, E Di Gregorio, G Miolo, A Steffan, G Corona - Metabolites, 2020 - mdpi.com
Ovarian cancer is considered a silent killer due to the lack of clear symptoms and efficient
diagnostic tools that often lead to late diagnoses. Over recent years, the impelling need for …

Emerging ways to treat breast cancer: will promises be met?

P Samadi, S Saki, FK Dermani, M Pourjafar… - Cellular Oncology, 2018 - Springer
Background Breast cancer (BC) is the most common cancer among women and it is
responsible for more than 40,000 deaths in the United States and more than 500,000 deaths …

Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells

L Chen, X Cheng, W Tu, Z Qi, H Li, F Liu, Y Yang… - Cellular Oncology, 2019 - Springer
Background Apatinib is a tyrosine kinase inhibitor that targets vascular endothelial growth
factor receptor-2 (VEGFR2), and has shown encouraging therapeutic effects in various …

Wide-targeted metabolome analysis identifies potential biomarkers for prognosis prediction of epithelial ovarian cancer

E Hishinuma, M Shimada, N Matsukawa, D Saigusa… - Toxins, 2021 - mdpi.com
Epithelial ovarian cancer (EOC) is a fatal gynecologic cancer, and its poor prognosis is
mainly due to delayed diagnosis. Therefore, biomarker identification and prognosis …

Emerging role of mucins in antibody drug conjugates for ovarian cancer therapy

S Malik, M Sikander, N Bell, D Zubieta, MC Bell… - Journal of Ovarian …, 2024 - Springer
Ovarian cancer stands as the deadliest gynecologic malignancy, responsible for nearly 65%
of all gynecologic cancer-related deaths. The challenges in early detection and diagnosis …

[HTML][HTML] A nine-gene signature related to tumor microenvironment predicts overall survival with ovarian cancer

QI Ding, S Dong, R Wang, K Zhang, H Wang… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Mounting evidence suggests that immune cell infiltration within the tumor microenvironment
(TME) is a crucial regulator of carcinogenesis and therapeutic efficacy in ovarian cancer …

Decoding colorectal cancer epigenomics

K El Bairi, K Tariq, I Himri, A Jaafari, W Smaili… - Cancer genetics, 2018 - Elsevier
Highlights•Epigenetic alterations are an emerging factor in colorectal carcinogenesis.•The
discovery of epigenetic pathways constitutes a major advance in cancer biomarker …

MiR-424-3p suppresses galectin-3 expression and sensitizes ovarian cancer cells to cisplatin

D Bieg, D Sypniewski, E Nowak, I Bednarek - Archives of Gynecology and …, 2019 - Springer
Abstract Purpose Assessment of miR-424-3p mimic capability to sensitize SK-OV-3 and TOV-
21G ovarian cancer cells to cisplatin by decreasing the expression of galectin-3, which is an …

Potent immunogenicity in BRCA1‐mutated patients with high‐grade serous ovarian carcinoma

Y Dai, C Sun, Y Feng, Q Jia… - Journal of Cellular and …, 2018 - Wiley Online Library
High‐grade serous ovarian carcinomas (HGSOC s) were among the tumours with an
unsatisfactory outcome of immune checkpoint inhibitors (ICI s). It is imperative to develop …

Effects of endocrine-disrupting chemicals and epigenetic modifications in ovarian cancer: a review

R Samtani, N Sharma, D Garg - Reproductive Sciences, 2018 - journals.sagepub.com
Ovarian cancer (OC) is a relatively fatal female reproductive malignancy. Since the
underlying causes are uncertain, it brings us to believe that both genetic and external factors …