Mobile genetic element flexibility as an underlying principle to bacterial evolution
Mobile genetic elements are key to the evolution of bacteria and traits that affect host and
ecosystem health. Here, we use a framework of a hierarchical and modular system that …
ecosystem health. Here, we use a framework of a hierarchical and modular system that …
Genome-resolved metagenomics: a game changer for microbiome medicine
N Kim, J Ma, W Kim, J Kim, P Belenky… - Experimental & Molecular …, 2024 - nature.com
Recent substantial evidence implicating commensal bacteria in human diseases has given
rise to a new domain in biomedical research: microbiome medicine. This emerging field …
rise to a new domain in biomedical research: microbiome medicine. This emerging field …
Pharokka: a fast scalable bacteriophage annotation tool
In recent years, there has been an increasing interest in bacteriophages, which has led to
growing numbers of bacteriophage genomic sequences becoming available. Consequently …
growing numbers of bacteriophage genomic sequences becoming available. Consequently …
[HTML][HTML] Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection
JA Nick, RM Dedrick, AL Gray, EK Vladar, BE Smith… - Cell, 2022 - cell.com
Two mycobacteriophages were administered intravenously to a male with treatment-
refractory Mycobacterium abscessus pulmonary infection and severe cystic fibrosis lung …
refractory Mycobacterium abscessus pulmonary infection and severe cystic fibrosis lung …
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen
Klebsiella pneumoniae is a major cause of opportunistic healthcare-associated infections,
which are increasingly complicated by the presence of extended-spectrum beta-lactamases …
which are increasingly complicated by the presence of extended-spectrum beta-lactamases …
A catalogue of 1,167 genomes from the human gut archaeome
The human gut microbiome plays an important role in health, but its archaeal diversity
remains largely unexplored. In the present study, we report the analysis of 1,167 …
remains largely unexplored. In the present study, we report the analysis of 1,167 …
Integrating cultivation and metagenomics for a multi-kingdom view of skin microbiome diversity and functions
Human skin functions as a physical barrier to foreign pathogen invasion and houses
numerous commensals. Shifts in the human skin microbiome have been associated with …
numerous commensals. Shifts in the human skin microbiome have been associated with …
Stepwise pathogenic evolution of Mycobacterium abscessus
JM Bryant, KP Brown, S Burbaud, I Everall… - Science, 2021 - science.org
INTRODUCTION Nearly all mycobacterial species are free-living environmental
saprophytes. A few, such as Mycobacterium tuberculosis, have evolved to cause …
saprophytes. A few, such as Mycobacterium tuberculosis, have evolved to cause …
The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional map**
BS Beresford-Jones, SC Forster, MD Stares, G Notley… - Cell host & …, 2022 - cell.com
Human health and disease have increasingly been shown to be impacted by the gut
microbiota, and mouse models are essential for investigating these effects. However, the …
microbiota, and mouse models are essential for investigating these effects. However, the …
Evolution and host-specific adaptation of Pseudomonas aeruginosa
The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant
infections in people with underlying immunodeficiencies or structural lung diseases such as …
infections in people with underlying immunodeficiencies or structural lung diseases such as …