Cancer cells are commonly aneuploid. The spindle checkpoint ensures accurate
chromosome segregation by controlling cell cycle progression in response to aberrant …

Polo-like kinases are essential cell cycle regulators that are conserved from yeast to
humans. Unlike higher eukaryotes, who express multiple Polo-like kinase family members …

Summary The Saccharomyces cerevisiae RSC (Remodel the Structure of Chromatin)
complex is a chromatin-remodeling complex and plays essential roles in transcription …

Abnormal nuclear size and shape are hallmarks of aging and cancer [1, 2]. However, the
mechanisms regulating nuclear morphology and nuclear envelope (NE) expansion are …

Evolutionarily conserved polo-like kinase, Cdc5 (Plk1 in humans), associates with
kinetochores during mitosis; however, the role of cell cycle–dependent centromeric (CEN) …

In eukaryotes, DNA is packaged into chromatin and is therefore relatively inaccessible to
DNA repair enzymes. In order to perform efficient DNA repair, ATP-dependent chromatin …

Cryptococcus neoformans is an opportunistic, human fungal pathogen which undergoes
fascinating switches in cell cycle control and ploidy when it encounters stressful …

ATP depletion inhibits cell cycle progression, especially during the G1 phase and the G2 to
M transition. However, the effect of ATP depletion on mitotic progression remains unclear …

The kinetochore, a multi-protein complex assembled on centromeres, is essential to
segregate chromosomes during cell division. Deficiencies in kinetochore function can lead …

Improperly attached chromosomes activate the mitotic checkpoint that arrests cell division
before anaphase. Cells can maintain an arrest for several hours but eventually will resume …