To understand biological processes, it is necessary to reveal the molecular heterogeneity of
cells by gaining access to the location and interaction of all biomolecules. Significant …

A growing community is constructing a next-generation file format (NGFF) for bioimaging to
overcome problems of scalability and heterogeneity. Organized by the Open Microscopy …

A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …

Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by
the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host …

Gut inflammation involves contributions from immune and non-immune cells, whose
interactions are shaped by the spatial organization of the healthy gut and its remodeling …

Anatomy of large biological specimens is often reconstructed from serially sectioned
volumes imaged by high-resolution microscopy. We developed a method to reassemble a …

Transcription initiation by RNA polymerase II (RNA Pol II) requires preinitiation complex
(PIC) assembly at gene promoters. In the dynamic nucleus, where thousands of promoters …

Nuclear speckles are nuclear membraneless organelles in higher eukaryotic cells playing a
vital role in gene expression. Using an in situ reverse transcription–based sequencing …

Necroptosis is a lytic form of regulated cell death reported to contribute to inflammatory
diseases of the gut, skin and lung, as well as ischemic-reperfusion injuries of the kidney …

Understanding the dynamics of RNA targeting to membraneless organelles is essential to
disentangle their functions. Here, we investigate how P-bodies (PBs) evolve during cell …