[HTML][HTML] The Pivotal Role of Preclinical Animal Models in Anti-Cancer Drug Discovery and Personalized Cancer Therapy Strategies

H Guo, X Xu, J Zhang, Y Du, X Yang, Z He, L Zhao… - Pharmaceuticals, 2024 - mdpi.com
The establishment and utilization of preclinical animal models constitute a pivotal aspect
across all facets of cancer research, indispensably contributing to the comprehension of …

[HTML][HTML] Deciphering the Blood–Brain Barrier Paradox in Brain Metastasis Development and Therapy

JJ Peters, C Teng, K Peng, X Li - Cancers, 2025 - mdpi.com
Gatekeeper or accomplice? That is the paradoxical role of the blood–brain barrier (BBB) in
develo** brain metastasis (BM). BM occurs when cancerous cells from primary cancer …

spatialGE is a User-Friendly Web Application that Facilitates Spatial Transcriptomics Data Analysis

OE Ospina, R Manjarres-Betancur… - Cancer …, 2024 - aacrjournals.org
Spatial transcriptomics (ST) is a powerful tool for understanding tissue biology and disease
mechanisms. However, the advanced data analysis and programming skills required can …

Metastatic brain tumors: from development to cutting‐edge treatment

G Tanzhu, L Chen, J Ning, W Xue, C Wang, G **ao… - MedComm, 2025 - Wiley Online Library
Metastatic brain tumors, also called brain metastasis (BM), represent a challenging
complication of advanced tumors. Tumors that commonly metastasize to the brain include …

Machine learning prediction of brain metastasis invasion pattern on brain magnetic resonance imaging scans

K Najafian, B Rehany, A Nowakowski… - Neuro-Oncology …, 2024 - academic.oup.com
Background Brain metastasis invasion pattern (BMIP) is an emerging biomarker associated
with recurrence-free and overall survival in patients, and differential response to therapy in …