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Spin hyperpolarization in modern magnetic resonance
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …
disciplines and in various practical applications, with medical magnetic resonance imaging …
[HTML][HTML] NMR spectroscopy for metabolomics research
Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …
three principal analytical techniques used in metabolomics (the other two being gas …
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer
Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that
favors cancer progression, therapy resistance and immune evasion. By single-cell RNA …
favors cancer progression, therapy resistance and immune evasion. By single-cell RNA …
Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …
Deuterium metabolic imaging (DMI) for MRI-based 3D map** of metabolism in vivo
Currently, the only widely available metabolic imaging technique in the clinic is positron
emission tomography (PET) detection of the radioactive glucose analog 2-18F-fluoro-2 …
emission tomography (PET) detection of the radioactive glucose analog 2-18F-fluoro-2 …
Glutamine and cancer: cell biology, physiology, and clinical opportunities
Glutamine is an abundant and versatile nutrient that participates in energy formation, redox
homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics …
homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics …
Parahydrogen‐based hyperpolarization for biomedicine
Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …
A molecular imaging primer: modalities, imaging agents, and applications
Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …
[HTML][HTML] Cellular metabolism and disease: what do metabolic outliers teach us?
An understanding of metabolic pathways based solely on biochemistry textbooks would
underestimate the pervasive role of metabolism in essentially every aspect of biology. It is …
underestimate the pervasive role of metabolism in essentially every aspect of biology. It is …
Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies
Cancer cells are well documented to rewire their metabolism and energy production
networks to support and enable rapid proliferation, continuous growth, survival in harsh …
networks to support and enable rapid proliferation, continuous growth, survival in harsh …