Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-
α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or …

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …

Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Microglial involvement in Alzheimer's disease (AD) pathology has emerged as a risk-
determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it …

Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …

The amyloid hypothesis for Alzheimer's disease (AD) posits a neuron-centric, linear cascade
initiated by Aβ and leading to dementia. This direct causality is incompatible with clinical …

Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …