Triclosan exposure, transformation, and human health effects

LM Weatherly, JA Gosse - Journal of Toxicology and …, 2017 - Taylor & Francis
Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the US population is
likely exposed to this compound via consumer goods and personal care products. In …

Targeting cell cycle regulation in cancer therapy

S Diaz-Moralli, M Tarrado-Castellarnau… - Pharmacology & …, 2013 - Elsevier
Cell proliferation is an essential mechanism for growth, development and regeneration of
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …

Nanotoxic effects of silver nanoparticles on normal HEK-293 cells in comparison to cancerous HeLa cell line

X Liu, K Shan, X Shao, X Shi, Y He, Z Liu… - International journal …, 2021 - Taylor & Francis
Purpose Biomimetic approaches for the synthesis of silver nanoparticles (AgNPs) had
created a substantial impression among the research community that focuses on nano-bio …

Triclosan: an update on biochemical and molecular mechanisms

MA Alfhili, MH Lee - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in
commercial and healthcare products. Items made with TCS include soaps, deodorants …

Is Triclosan a neurotoxic agent?

JA Ruszkiewicz, S Li, MB Rodriguez… - Journal of Toxicology …, 2017 - Taylor & Francis
Triclosan (TCS) is an antibacterial agent that has been used in many products since 1960s.
Given its broad usage as an antiseptic TCS is present ubiquitously in the environment. Trace …

Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy

A Schcolnik-Cabrera, A Chávez-Blanco… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Cancer cells have increased glycolysis and glutaminolysis. Their third feature is
increased de novo lipogenesis. As such, fatty acid (FA) synthesis enzymes are over …

[HTML][HTML] The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer

MC Sadowski, RH Pouwer, JH Gunter, AA Lubik… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Inhibition of FASN has emerged as a promising therapeutic target in cancer, and numerous
inhibitors have been investigated. However, severe pharmacological limitations have …

Triclosan: Antimicrobial mechanisms, antibiotics interactions, clinical applications, and human health

P Shrestha, Y Zhang, WJ Chen… - Journal of Environmental …, 2020 - Taylor & Francis
The large-scale applications of Triclosan in industrial and household products have created
many health and environmental concerns. Despite the fears of its drug-resistance and other …

Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress

S Rodríguez-Enríquez, SC Pacheco-Velázquez… - Toxicology and applied …, 2019 - Elsevier
The resveratrol (RSV) efficacy to affect the proliferation of several cancer cell lines was
initially examined. RSV showed higher potency to decrease growth of metastatic HeLa and …

The fatty acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas

M Agostini, LY Almeida, DC Bastos, RM Ortega… - Molecular cancer …, 2014 - AACR
Fatty acid synthase (FASN) is the biosynthetic enzyme responsible for the endogenous
synthesis of fatty acids. It is downregulated in most normal cells, except in lipogenic tissues …