Nasopharyngeal carcinoma: an evolving paradigm

KCW Wong, EP Hui, KW Lo, WKJ Lam… - Nature reviews Clinical …, 2021‏ - nature.com
The past three decades have borne witness to many advances in the understanding of the
molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein–Barr virus …

Overview of the 8th edition TNM classification for head and neck cancer

SH Huang, B O'Sullivan - Current treatment options in oncology, 2017‏ - Springer
Opinion Statement The main purpose of the TNM system is to provide an anatomic-based
classification to adequately depict cancer prognosis. Accurate cancer staging is important for …

Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS–ESMO–ESTRO Clinical Practice Guidelines for diagnosis, treatment and …

JP Machiels, CR Leemans, W Golusinski… - Annals of …, 2020‏ - annalsofoncology.org
Squamous cell carcinoma of the head and neck (SCCHN) arises from epithelial cells and
occurs in the oral cavity, pharynx and larynx. Nasopharyngeal carcinoma (NPC) is a disease …

Effect of radiotherapy alone vs radiotherapy with concurrent chemoradiotherapy on survival without disease relapse in patients with low-risk nasopharyngeal …

LL Tang, R Guo, N Zhang, B Deng, L Chen, ZB Cheng… - Jama, 2022‏ - jamanetwork.com
Importance Concurrent chemoradiotherapy has been the standard treatment for stage II
nasopharyngeal carcinoma (NPC) based on data using 2-dimensional conventional …

Nasopharyngeal carcinoma: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

P Bossi, AT Chan, L Licitra, A Trama… - Annals of …, 2021‏ - annalsofoncology.org
Nasopharyngeal carcinoma (NPC) is a disease with unique epidemiological features. The
distribution of the disease demonstrates a clear regional, racial and gender prevalence. In …

CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG …

CL Brouwer, RJHM Steenbakkers, J Bourhis… - Radiotherapy and …, 2015‏ - Elsevier
Purpose The objective of this project was to define consensus guidelines for delineating
organs at risk (OARs) for head and neck radiotherapy for routine daily practice and for …

Comparing deep learning-based auto-segmentation of organs at risk and clinical target volumes to expert inter-observer variability in radiotherapy planning

J Wong, A Fong, N McVicar, S Smith… - Radiotherapy and …, 2020‏ - Elsevier
Background Deep learning-based auto-segmented contours (DC) aim to alleviate labour
intensive contouring of organs at risk (OAR) and clinical target volumes (CTV). Most …

Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre …

LL Tang, CL Huang, N Zhang, W Jiang, YS Wu… - The Lancet …, 2022‏ - thelancet.com
Background The aim of this trial was to address whether elective ipsilateral upper-neck
irradiation (UNI) sparing the uninvolved lower neck provides similar regional relapse-free …

International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma

AW Lee, WT Ng, JJ Pan, SS Poh, YC Ahn… - Radiotherapy and …, 2018‏ - Elsevier
Purpose Target delineation in nasopharyngeal carcinoma (NPC) often proves challenging
because of the notoriously narrow therapeutic margin. High doses are needed to achieve …

ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer

BV Offersen, LJ Boersma, C Kirkove, S Hol… - Radiotherapy and …, 2015‏ - Elsevier
Background and purpose Delineation of clinical target volumes (CTVs) is a weak link in
radiation therapy (RT), and large inter-observer variation is seen in breast cancer patients …