Enabling pathway design by multiplex experimentation and machine learning

AG Boob, J Chen, H Zhao - Metabolic Engineering, 2024 - Elsevier
The remarkable metabolic diversity observed in nature has provided a foundation for
sustainable production of a wide array of valuable molecules. However, transferring the …

Microbial assimilation of lignin-derived aromatic compounds and conversion to value-added products

CC Azubuike, MN Allemann, JK Michener - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Depolymerized lignin is a complex and variable mix of aromatic compounds.•Non-
model microbes can convert these aromatic compounds to useful products.•Known microbial …

[HTML][HTML] Guiding stars to the field of dreams: Metabolically engineered pathways and microbial platforms for a sustainable lignin-based industry

F Weiland, M Kohlstedt, C Wittmann - Metabolic engineering, 2022 - Elsevier
Lignin is an important structural component of terrestrial plants and is readily generated
during biomass fractionation in lignocellulose processing facilities. Due to lacking …

Perspective on lignin conversion strategies that enable next generation biorefineries

S Shrestha, S Goswami, D Banerjee, V Garcia… - …, 2024 - Wiley Online Library
The valorization of lignin, a currently underutilized component of lignocellulosic biomass,
has attracted attention to promote a stable and circular bioeconomy. Successful approaches …

Pickaxe: a Python library for the prediction of novel metabolic reactions

KM Shebek, J Strutz, LJ Broadbelt, KEJ Tyo - BMC bioinformatics, 2023 - Springer
Background Biochemical reaction prediction tools leverage enzymatic promiscuity rules to
generate reaction networks containing novel compounds and reactions. The resulting …

Deciphering the driving mechanism of microbial community for rapid stabilization and lignocellulose degradation during waste semi-aerobic bioreactor landfilling with …

M Wu, Y Tao, Q Zeng, Z Pan, H Zhang, Z Yin, W Li… - Waste Management, 2025 - Elsevier
Owing to the massive refractory lignocellulose and leachate-organic loads, the stabilization
of municipal solid waste (MSW) landfill is often prolonged, resulting in environmental …

Computational Approaches for the Design and Screening of Novel Biopolymers

K Shebek - 2024 - search.proquest.com
Reliance on polymers produced from traditional fossil fuel feedstocks has led to an increase
in greenhouse gas emissions and long-lived waste in the environment. Biopolymers offer an …

Develo** and Applying Acinetobacter baylyi ADP1 as a Host for Lignin-Based Metabolic Engineering

BW Biggs - 2021 - search.proquest.com
To achieve globally outlined sustainability goals, multiple fields and a range of approaches
will be required. Built upon the inherent advantages of biological chemistry, biological …