The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early
brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies have indicated …

Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1
(ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in …

Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1–
7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of …

Abstract Purpose of Review Although an independent brain renin-angiotensin system is
often assumed to exist, evidence for this concept is weak. Most importantly, renin is lacking …

Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated
encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a …

Aims Osteoarthritis (OA) is the most common chronic pathema of human joints. The
pathogenesis is complex, involving physiological and mechanical factors. In previous …

Activation of the renin-angiotensin system (RAS), by Angiotensin converting
enzyme/Angiotensin II/Angiotensin receptor-1 (ACE/Ang II/AT1 R) axis elicits amyloid …