Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Engineered gene drives—the process of stimulating the biased inheritance of specific genes—
have the potential to enable the spread of desirable genes throughout wild populations or to …

The renewed effort to eliminate malaria and permanently remove its tremendous burden
highlights questions of what combination of tools would be sufficient in various settings and …

Yellow fever virus (YFV) is the prototype member of the genus Flavivirus, a group of viruses
that are transmitted between vertebrates by arthropod vectors. The virus is found in tropical …

Drosophila has long been a premier model for the development and application of cutting-
edge genetic approaches. The CRISPR-Cas system now adds the ability to manipulate the …

The elegant mechanisms by which naturally occurring selfish genetic elements, such as
transposable elements, meiotic drive genes, homing endonuclease genes and Wolbachia …

Mosquitoes (Aedes aegypti) were genetically modified to exhibit impaired vector
competence for dengue type 2 viruses (DENV-2). We exploited the natural antiviral RNA …

Gene drive technology offers the promise for a high-impact, cost-effective, and durable
method to control malaria transmission that would make a significant contribution to …

One proposed strategy for controlling the transmission of insect-borne pathogens uses a
drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness …

Homing endonuclease genes (HEGs) encode proteins that in the heterozygous state cause
double-strand breaks in the homologous chromosome at the precise position opposite the …