The direct functionalization of C (sp3)–H bonds represents one of the most investigated
approaches to develop new synthetic methodology. Among the available strategies for …

In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …

Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …

Recognizing Nature's unique ability to perform challenging oxygenation reactions with
exquisite selectivity parameters at iron-dependent oxygenases, chemists have long sought …

Reactions that enable selective functionalization of strong aliphatic C–H bonds open new
synthetic paths to rapidly increase molecular complexity and expand chemical space …

First-row transition-metal-mediated reactions constitute an important and growing area of
research due to the low cost, low toxicity, and exceptional synthetic versatility of these …

Aliphatic C–H bond functionalization is at the frontline of research because it can provide
straightforward access to simplified and cost-effective synthetic procedures. A number of …

The selective oxidation of hydrocarbons is a challenging reaction for synthetic chemists, but
common in nature. Iron oxygenases activate the O–O bond of dioxygen to perform oxidation …

Enzymes are highly efficient catalysts in Nature that often react with high stereo-, chemo-,
and regioselectivity. Usually, enzymes achieve this selectivity through substrate binding and …

Monosubstituted cycloalkanes undergo regio-and enantioselective aliphatic C–H oxidation
with H2O2 catalyzed by biologically inspired manganese catalysts. The reaction furnishes …