Epigenetics in natural animal populations
Phenotypic plasticity is an important mechanism for populations to buffer themselves from
environmental change. While it has long been appreciated that natural populations possess …
environmental change. While it has long been appreciated that natural populations possess …
Ten years of EWAS
S Wei, J Tao, J Xu, X Chen, Z Wang, N Zhang… - Advanced …, 2021 - Wiley Online Library
Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation
variation in complex diseases for a decade, and epigenome as a research target has …
variation in complex diseases for a decade, and epigenome as a research target has …
Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
Background DNA methylation is one of the main epigenetic mechanisms for the regulation of
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
Glioblastoma is characterized by widespread genetic and transcriptional heterogeneity, yet
little is known about the role of the epigenome in glioblastoma disease progression. Here …
little is known about the role of the epigenome in glioblastoma disease progression. Here …
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma
Developmental tumors in children and young adults carry few genetic alterations, yet they
have diverse clinical presentation. Focusing on Ewing sarcoma, we sought to establish the …
have diverse clinical presentation. Focusing on Ewing sarcoma, we sought to establish the …
Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species
Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …
implicated in various regulatory mechanisms across the animal kingdom and particularly in …
An ecologist's guide for studying DNA methylation variation in wild vertebrates
The field of molecular biology is advancing fast with new powerful technologies, sequencing
methods and analysis software being developed constantly. Commonly used tools originally …
methods and analysis software being developed constantly. Commonly used tools originally …
Integrated multiomic profiling identifies the epigenetic regulator PRC2 as a therapeutic target to counteract leukemia immune escape and relapse
V Gambacorta, S Beretta, M Ciccimarra, L Zito… - Cancer Discovery, 2022 - AACR
Immune escape represents a major driver of acute myeloid leukemia (AML) reemergence
after allogeneic hematopoietic cell transplantation (allo-HCT), with up to 40% of relapses …
after allogeneic hematopoietic cell transplantation (allo-HCT), with up to 40% of relapses …
The genetics and epigenetics of animal migration and orientation: birds, butterflies and beyond
Migration is a complex behavioural adaptation for survival that has evolved across the
animal kingdom from invertebrates to mammals. In some taxa, closely related migratory …
animal kingdom from invertebrates to mammals. In some taxa, closely related migratory …
Guadecitabine plus ipilimumab in unresectable melanoma: the NIBIT-M4 clinical trial
Purpose: The immunomodulatory activity of DNA hypomethylating agents (DHAs) suggests
they may improve the effectiveness of cancer immunotherapies. The phase Ib NIBIT-M4 trial …
they may improve the effectiveness of cancer immunotherapies. The phase Ib NIBIT-M4 trial …