Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease
characterized by degeneration of upper and lower motor neurons in the brain and spinal …

Eukaryotic cells express a large variety of RNA binding proteins (RBPs), with diverse
affinities and specificities towards target RNAs. These proteins play a crucial role in almost …

Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Direct delivery of proteins and peptides into living mammalian cells has been accomplished
using phospholipid liposomes as carrier particles. Such liposomes are usually taken up via …

RNA is the fundamental information transfer system in the cell. The ability to follow single
messenger RNAs (mRNAs) from transcription to degradation with fluorescent probes gives …

The in vivo characterization of the exact copy number and the specific function of each
composite protein within the nuclear pore complex (NPC) remains both desirable and …

Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step
of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of …

Nuclear export of messenger RNA (mRNA) through the nuclear pore complex (NPC) is an
indispensable step to ensure protein translation in the cytoplasm of eukaryotic cells. mRNA …

The flow of genetic information is regulated by selective nucleocytoplasmic transport of
messenger RNA: protein complexes (mRNPs) through the nuclear pore complexes (NPCs) …