Uniform transitions of the general RNA polymerase II transcription complex
A Mayer, M Lidschreiber, M Siebert, K Leike… - Nature structural & …, 2010 - nature.com
We present genome-wide occupancy profiles for RNA polymerase (Pol) II, its
phosphorylated forms and transcription factors in proliferating yeast. Pol II exchanges …
phosphorylated forms and transcription factors in proliferating yeast. Pol II exchanges …
Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast
To obtain rates of mRNA synthesis and decay in yeast, we established dynamic
transcriptome analysis (DTA). DTA combines non‐perturbing metabolic RNA labeling with …
transcriptome analysis (DTA). DTA combines non‐perturbing metabolic RNA labeling with …
TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein
The TRIM37 (also known as MUL) gene is located in the 17q23 chromosomal region, which
is amplified in up to∼ 40% of breast cancers. TRIM37 contains a RING finger domain, a …
is amplified in up to∼ 40% of breast cancers. TRIM37 contains a RING finger domain, a …
Genome scale patterns of supercoiling in a bacterial chromosome
DNA in bacterial cells primarily exists in a negatively supercoiled state. The extent of
supercoiling differs between regions of the chromosome, changes in response to external …
supercoiling differs between regions of the chromosome, changes in response to external …
Functional analysis of CTCF during mammalian limb development
N Soshnikova, T Montavon, M Leleu, N Galjart… - Developmental cell, 2010 - cell.com
CCCTC-binding factor (CTCF) is a nuclear zinc-finger protein that displays insulating activity
in a variety of biological assays. For example, CTCF-binding sites have been suggested to …
in a variety of biological assays. For example, CTCF-binding sites have been suggested to …
NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets
R Bouveret, AJ Waardenberg, N Schonrock… - elife, 2015 - elifesciences.org
We take a functional genomics approach to congenital heart disease mechanism. We used
DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated …
DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated …
DNA methylation mediated control of gene expression is critical for development of crown gall tumors
J Gohlke, CJ Scholz, S Kneitz, D Weber, J Fuchs… - PLoS …, 2013 - journals.plos.org
Crown gall tumors develop after integration of the T-DNA of virulent Agrobacterium
tumefaciens strains into the plant genome. Expression of the T-DNA–encoded oncogenes …
tumefaciens strains into the plant genome. Expression of the T-DNA–encoded oncogenes …
Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster
Forkhead box O (FoxO) transcription factors (TFs) are key drivers of complex transcriptional
programmes that determine animal lifespan. FoxOs regulate a number of other TFs, but how …
programmes that determine animal lifespan. FoxOs regulate a number of other TFs, but how …
A nucleosome turnover map reveals that the stability of histone H4 Lys20 methylation depends on histone recycling in transcribed chromatin
JP Svensson, M Shukla, V Menendez-Benito… - Genome …, 2015 - genome.cshlp.org
Nucleosome composition actively contributes to chromatin structure and accessibility. Cells
have developed mechanisms to remove or recycle histones, generating a landscape of …
have developed mechanisms to remove or recycle histones, generating a landscape of …
Structural determinants of DNA recognition by plant MADS-domain transcription factors
Plant MADS-domain transcription factors act as key regulators of many developmental
processes. Despite the wealth of information that exists about these factors, the mechanisms …
processes. Despite the wealth of information that exists about these factors, the mechanisms …