Adherens junctions as molecular regulators of emergent tissue mechanics
Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …
coordinated action of many cells. Recent studies have revealed that tissue material …
Mechanochemical feedback loops in development and disease
There is increasing evidence that both mechanical and biochemical signals play important
roles in development and disease. The development of complex organisms, in particular …
roles in development and disease. The development of complex organisms, in particular …
The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …
taste, touch, and proprioception) to help them to react properly to their environment. The …
Cell and nucleus shape as an indicator of tissue fluidity in carcinoma
Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell
cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated …
cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated …
Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β‐catenin signaling
X Tian, Y Wu, Y Yang, J Wang, M Niu, S Gao… - Molecular …, 2020 - Wiley Online Library
Tumor‐associated macrophages have important roles in hepatocellular carcinoma (HCC)
initiation and progression. Long noncoding RNAs (lncRNAs) have also been reported to be …
initiation and progression. Long noncoding RNAs (lncRNAs) have also been reported to be …
[HTML][HTML] The mechanics of mitotic cell rounding
When animal cells enter mitosis, they round up to become spherical. This shape change is
accompanied by changes in mechanical properties. Multiple studies using different …
accompanied by changes in mechanical properties. Multiple studies using different …
Embryonic tissues as active foams
The physical state of embryonic tissues emerges from non-equilibrium, collective
interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics …
interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics …
Tissue fluidity promotes epithelial wound healing
The collective behaviour of cells in epithelial tissues is dependent on their mechanical
properties. However, the contribution of tissue mechanics to wound healing in vivo remains …
properties. However, the contribution of tissue mechanics to wound healing in vivo remains …
Morphogens enable interacting supracellular phases that generate organ architecture
During vertebrate organogenesis, increases in morphological complexity are tightly coupled
to morphogen expression. In this work, we studied how morphogens influence self …
to morphogen expression. In this work, we studied how morphogens influence self …
Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions
Embryo morphogenesis is impacted by dynamic changes in tissue material properties,
which have been proposed to occur via processes akin to phase transitions (PTs). Here, we …
which have been proposed to occur via processes akin to phase transitions (PTs). Here, we …