This review reexamines the results obtained in recent decades regarding the compatibility
polymorphism between the snail, Biomphalaria glabrata, and the pathogen, Schistosoma …

T. cruzi has a complex life cycle involving four developmental stages namely, epimastigotes,
metacyclic trypomastigotes, amastigotes and bloodstream trypomastigotes. Although …

Trypanosoma cruzi is a complex of phenotypically and genetically diverse isolates
distributed in six discrete ty** units (DTUs) designated as TcI–TcVI. Five years ago, T …

The cysteine proteases, cruzain and Tbr CATL (rhodesain), are therapeutic targets for
Chagas disease and Human African Trypanosomiasis, respectively. Among the known …

Cruzipains are the main papain-like cysteine proteases of Trypanosoma cruzi, the protozoan
parasite that causes Chagas disease. Encoded by a multigenic family, previous studies …

Over 110 years after the first formal description of Chagas disease, the trypanocidal drugs
thus far available have limited efficacy and several side effects. This encourages the search …

Trypanosoma cruzi is the causal agent of Chagas' disease which affects millions of people
around the world mostly in Central and South America. T. cruzi expresses a wide variety of …

Background Bat trypanosomes have been implicated in the evolutionary history of the T.
cruzi clade, which comprises species from a wide geographic and host range in South …

Trypanosoma rangeli and Trypanosoma cruzi are generalist trypanosomes sharing a wide
range of mammalian hosts; they are transmitted by triatomine bugs, and are the only …

Comparing the population structure of Trypanosoma cruzi with that of other pathogens,
including parasitic protozoa, fungi, bacteria and viruses, shows that the agent of Chagas …