The involvement of nitric oxide synthase neurons in enteric neuropathies

LR Rivera, DP Poole, M Thacker… - Neurogastroenterology …, 2011 - Wiley Online Library
Nitric oxide (NO), produced by the neural nitric oxide synthase enzyme (nNOS) is a
transmitter of inhibitory neurons supplying the muscle of the gastrointestinal tract …

Chagas' disease and the autoimmunity hypothesis

F Kierszenbaum - Clinical microbiology reviews, 1999 - Am Soc Microbiol
The notion that the pathology of Chagas' disease has an autoimmune component was
initially based on the finding of circulating antibodies binding heart tissue antigens in …

Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry

E Cunha-Neto, AM Bilate, KV Hyland, SG Fonseca… - …, 2006 - Taylor & Francis
Up to 18 million of individuals are infected by the protozoan parasite Trypanosoma cruzi in
Latin America, one third of whom will develop chronic Chagas disease cardiomyopathy …

Antibodies in the pathogenesis of hypertension

CT Chan, M Lieu, BH Toh, TS Kyaw… - BioMed Research …, 2014 - Wiley Online Library
It has long been known that circulating levels of IgG and IgM antibodies are elevated in
patients with essential and pregnancy‐related hypertension. Recent studies indicate these …

Cardiac myosin autoimmunity in acute Chagas' heart disease

JS Leon, LM Godsel, K Wang… - Infection and …, 2001 - Am Soc Microbiol
Infection with Trypanosoma cruzi, the agent of Chagas' disease, may induce antibodies and
T cells reactive with self antigens (autoimmunity). Because autoimmunity is generally …

[HTML][HTML] Ca2+ currents in cardiac myocytes: old story, new insights

F Brette, J Leroy, JY Le Guennec, L Sallé - Progress in biophysics and …, 2006 - Elsevier
Calcium is a ubiquitous second messenger which plays key roles in numerous physiological
functions. In cardiac myocytes, Ca2+ crosses the plasma membrane via specialized voltage …

[PDF][PDF] Functional autoantibody diseases: Basics and treatment related to cardiomyopathies

NP Becker, P Goettel, J Mueller… - … Biosci (Landmark Ed …, 2019 - article.imrpress.com
Protein- mediated enamel mineralization Page 1 48 Functional autoantibody diseases: Basics
and treatment related to cardiomyopathies Niels-Peter Becker1, Peter Goettel1, Johannes …

Decreased autophagy in rat heart induced by anti-β1-adrenergic receptor autoantibodies contributes to the decline in mitochondrial membrane potential

L Wang, K Lu, H Hao, X Li, J Wang, K Wang, J Wang… - PloS one, 2013 - journals.plos.org
It has been recognized that changes in mitochondrial structure plays a key role in
development of cardiac dysfunction, and autophagy has been shown to exert maintenance …

Drug‐like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function

LR Herda, SB Felix, F Boege - British journal of pharmacology, 2012 - Wiley Online Library
Antibodies against cholinergic and adrenergic receptors (adrenoceptors) are frequent in
serum of patients with chronic heart failure. Their prevalence is associated with Chagas' …

Views on the autoimmunity hypothesis for Chagas disease pathogenesis

F Kierszenbaum - FEMS Immunology & Medical Microbiology, 2003 - academic.oup.com
Initially, the notion that the pathogenesis of Chagas disease has an autoimmune component
was based on the finding that sera from Trypanosoma cruzi-infected patients or laboratory …