Antipsychotic sensitization and tolerance refer to the increased and decreased drug effects
due to past drug use, respectively. Both effects reflect the long-term impacts of antipsychotic …

Autism spectrum disorders (ASD) are characterized by altered sociability, compromised
communication and stereotyped/repetitive behaviors, for which no specific treatments are …

There is emerging evidence that the endocannabinoid system (ECS) plays a significant role
in the pathophysiology of many psychiatric disorders, including attention deficit hyperactivity …

Rationale The information processing appears to be deficient in schizophrenia. Prepulse
inhibition (PPI), which measures the inhibition of a motor response by a weak sensory event …

Abstract L-DOPA-induced dyskinesia (LID) is a significant complication of dopamine
replacement therapy in Parkinson's disease (PD), and the specific role of different dopamine …

Background and Purpose The endocannabinoids anandamide and 2‐arachidonoylglycerol
(2‐AG) bind to CB1 and CB2 cannabinoid receptors in the brain and modulate the …

Background Mood disorders, including anxiety and depression, are frequently diagnosed in
multiple sclerosis (MS) patients, even independently of the disabling symptoms associated …

Lysosomal storage disorders characterized by defective heparan sulfate (HS) degradation,
such as Mucopolysaccharidosis type IIIA-D (MPS-IIIA-D), result in neurodegeneration and …

Background: Endocannabinoids modulate the glutamatergic excitatory transmission by
acting as retrograde messengers. A growing body of studies has reported that both signaling …

The endocannabinoid system has been implicated in the development of synaptic plasticity
induced by several drugs abused by humans, including cocaine. However, there remains …