Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …

Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an
early cellular response to the induction of DNA double-strand breaks. Detection of this …

Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

The discovery of new histone modifications is unfolding at startling rates; however, the
identification of effectors capable of interpreting these modifications has lagged behind …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …