Is heterosynaptic modulation essential for stabilizing hebbian plasiticity and memory

CH Bailey, M Giustetto, YY Huang… - Nature Reviews …, 2000 - nature.com
In 1894, Ramón y Cajal first proposed that memory is stored as an anatomical change in the
strength of neuronal connections. For the following 60 years, little evidence was recruited in …

Injury-related behavior and neuronal plasticity: an evolutionary perspective on sensitization, hyperalgesia, and analgesia

ET Walters - International review of neurobiology, 1994 - Elsevier
Publisher Summary This chapter discusses evolutionary aspects of injury-related behavior,
and examines behavioral, physiological, and molecular aspects of potentially adaptive …

Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change

D Bartsch, M Ghirardi, PA Skehel, KA Karl, SP Herder… - Cell, 1995 - cell.com
The switch from short-to long-term facilitation induced by behavioral sensitization in Aplysia
involves CREB-like proteins, as well as the immediate-early gene ApCIEBP. Using the bZlP …

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia

CM Alberini, M Ghirardl, R Metz, ER Kandel - Cell, 1994 - cell.com
The consolldatlon of long-term memory requires protein and mRNA synthesis. A slmllar
requlrement has been demonstrated for learning-related synaptic plasticity In the gill …

The massed-spaced learning effect in non-neural human cells

NV Kukushkin, RE Carney, T Tabassum… - Nature …, 2024 - nature.com
The massed-spaced effect is a hallmark feature of memory formation. We now demonstrate
this effect in two separate non-neural, immortalized cell lines stably expressing a short-lived …

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

YY Huang, XC Li, ER Kandel - Cell, 1994 - cell.com
Memory storage has a short-term phase that depends on preexisting proteins and a long-
term phase that requires new protein and RNA synthesis. Hippocampal long-term …

[HTML][HTML] Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia

AN Hegde, K Inokuchi, W Pei, A Casadio, M Ghirardi… - Cell, 1997 - cell.com
The switch from short-term to long-term facilitation of the synapses between sensory and
motor neurons mediating gill and tail withdrawal reflexes in Aplysia requires CREB …

A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices

PV Nguyen, ER Kandel - Journal of Neuroscience, 1996 - Soc Neuroscience
Memory storage consists of a short-term phase that is independent of new protein synthesis
and a long-term phase that requires the synthesis of new proteins and RNA. A cellular …

Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term …

YY Huang, KC Martin, ER Kandel - Journal of Neuroscience, 2000 - Soc Neuroscience
The lateral amygdala (LA) is thought to be critical for the specific acquisition of conditioned
fear, and the emotionally charged memories related to fear are thought to require a form of …

Brief theta-burst stimulation induces a transcription-dependent late phase of LTP requiring cAMP in area CA1 of the mouse hippocampus.

PV Nguyen, ER Kandel - Learning & memory, 1997 - learnmem.cshlp.org
Memory storage in the mammalian brain can be divided into a short-term phase that is
independent of new protein synthesis and a long-term phase that requires synthesis of new …