One of the recent paradigm shifts in stem cell biology has been the discovery that stem cells
can begin to differentiate into mature tissue cells when exposed to intrinsic properties of the …

Living tissues are active, multifunctional materials capable of generating, sensing,
withstanding and responding to mechanical stress. These capabilities enable tissues to …

The mechanical properties of the cellular microenvironment and their spatiotemporal
variations are thought to play a central role in sculpting embryonic tissues, maintaining …

Tissue-specific elastic modulus (E), or 'stiffness,'arises from developmental changes in the
extracellular matrix (ECM) and suggests that progenitor cell differentiation may be optimal …

Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

Develo** organs acquire a specific three-dimensional form that ensures their normal
function. Cardiac function, for example, depends upon properly shaped chambers that …

Force production and the propagation of stress and strain within embryos and organisms are
crucial physical processes that direct morphogenesis. In addition, there is mounting …

In development and differentiation, morphological changes often accompany mechanical
changes [1], but it is unclear whether or when cells in embryos sense tissue elasticity. The …

The sculpting of embryonic tissues and organs into their functional morphologies involves
the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in …

The spatial and temporal scales of cardiac organogenesis and pathogenesis make
engineering of artificial heart tissue a daunting challenge. The temporal scales range from …