The aging navigational system
The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …
functionally distinct cell types such as place and grid cells, combined with an extensive body …
[HTML][HTML] Neuroprotective action of resveratrol
Low-to-moderate red wine consumption appeared to reduce age-related neurological
disorders including macular degeneration, stroke, and cognitive deficits with or without …
disorders including macular degeneration, stroke, and cognitive deficits with or without …
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and
bind with high affinity to cellular prion protein (PrP C). At the postsynaptic density (PSD) …
bind with high affinity to cellular prion protein (PrP C). At the postsynaptic density (PSD) …
Neuroinflammation in the normal aging hippocampus
A consequence of normal aging is a greater susceptibility to memory impairments following
an immune challenge such as infection, surgery, or traumatic brain injury. The …
an immune challenge such as infection, surgery, or traumatic brain injury. The …
[HTML][HTML] Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of …
Murine studies showed that disruption of circadian clock rhythmicity could lead to cancer
and metabolic syndrome. Time-restricted feeding can reset the disrupted clock rhythm …
and metabolic syndrome. Time-restricted feeding can reset the disrupted clock rhythm …
The endocannabinoid system in normal and pathological brain ageing
A Bilkei-Gorzo - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
The role of endocannabinoids as inhibitory retrograde transmitters is now widely known and
intensively studied. However, endocannabinoids also influence neuronal activity by exerting …
intensively studied. However, endocannabinoids also influence neuronal activity by exerting …
Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition
P Denver, PL McClean - Neural regeneration research, 2018 - journals.lww.com
As populations age, prevalence of Alzheimer's disease (AD) is rising. Over 100 years of
research has provided valuable insights into the pathophysiology of the disease, for which …
research has provided valuable insights into the pathophysiology of the disease, for which …
Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain
A De Rosa, A Fontana, T Nuzzo, M Garofalo, A Di Maio… - Schizophrenia, 2022 - nature.com
Schizophrenia is a disorder of synaptic plasticity and aberrant connectivity in which a major
dysfunction in glutamate synapse has been suggested. However, a multi-level approach …
dysfunction in glutamate synapse has been suggested. However, a multi-level approach …
Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and …
Previous studies from our lab have demonstrated that mild cognitive impairments identified
early in life are predictive of cognitive deficits that develop with age, suggesting that …
early in life are predictive of cognitive deficits that develop with age, suggesting that …
Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways
LA Denner, J Rodriguez-Rivera… - Journal of …, 2012 - Soc Neuroscience
We previously reported that the peroxisome proliferator-activated receptor γ (PPARγ)
agonist rosiglitazone (RSG) improved hippocampus-dependent cognition in the Alzheimer's …
agonist rosiglitazone (RSG) improved hippocampus-dependent cognition in the Alzheimer's …