Clinical update on head and neck cancer: molecular biology and ongoing challenges
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …
Inside the hypoxic tumour: reprogramming of the DDR and radioresistance
K Begg, M Tavassoli - Cell Death Discovery, 2020 - nature.com
The hypoxic tumour is a chaotic landscape of struggle and adaption. Against the adversity of
oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities …
oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities …
[HTML][HTML] Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors
P Kosti, JW Opzoomer, KI Larios-Martinez… - Cell Reports …, 2021 - cell.com
Utilizing T cells expressing chimeric antigen receptors (CARs) to identify and attack solid
tumors has proven challenging, in large part because of the lack of tumor-specific targets to …
tumors has proven challenging, in large part because of the lack of tumor-specific targets to …
Integrating tumor hypoxic stress in novel and more adaptable strategies for cancer immunotherapy
Immunotherapy is poised to become an increasingly utilized therapy in the treatment of
cancer. However, several abnormalities in the tumor microenvironment (TME) that can …
cancer. However, several abnormalities in the tumor microenvironment (TME) that can …
PET/CT and PET/MRI in head and neck malignancy
Combined 2-[18 F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography
(PET)/computed tomography (CT) has an established role in the staging of difficult cases of …
(PET)/computed tomography (CT) has an established role in the staging of difficult cases of …
[HTML][HTML] Lost in application: Measuring hypoxia for radiotherapy optimisation
N Thiruthaneeswaran, BAS Bibby, L Yang… - European Journal of …, 2021 - Elsevier
The history of radiotherapy is intertwined with research on hypoxia. There is level 1a
evidence that giving hypoxia-targeting treatments with radiotherapy improves locoregional …
evidence that giving hypoxia-targeting treatments with radiotherapy improves locoregional …
Clinical imaging of hypoxia: Current status and future directions
Tissue hypoxia is a key feature of many important causes of morbidity and mortality. In
pathologies such as stroke, peripheral vascular disease and ischaemic heart disease …
pathologies such as stroke, peripheral vascular disease and ischaemic heart disease …
Hypoxia gene expression signatures as predictive biomarkers for personalising radiotherapy
Hypoxia is a generic micro-environmental factor of solid tumours. High levels of hypoxia
lead to resistance to radiotherapy, which can be targeted by adding hypoxia-modifying …
lead to resistance to radiotherapy, which can be targeted by adding hypoxia-modifying …
A prognostic gene expression signature for oropharyngeal squamous cell carcinoma
Background Robust prognostic stratification of patients with oropharyngeal squamous cell
carcinoma (OPSCC) is important for develo** individualized treatment plans. This study …
carcinoma (OPSCC) is important for develo** individualized treatment plans. This study …
[HTML][HTML] STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression
J Wang, J Shen, K Zhao, J Hu, J Dong… - Cancer Biology & …, 2019 - ncbi.nlm.nih.gov
Objective Stromal interaction molecule 1 (STIM1) overexpression has been reported to play
an important role in progression of several cancers. However, the mechanism of STIM1 …
an important role in progression of several cancers. However, the mechanism of STIM1 …