Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

Existing guidelines on the preparation (Planning Research and Experimental Procedures on
Animals: Recommendations for Excellence (PREPARE)) and reporting (Animal Research …

Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic
options. The mechanisms underlying LMS development, including clinically actionable …

Uterine leiomyosarcomas (uLMS) are rare, aggressive malignancies for which limited
treatment options are available. To gain novel molecular insights into uLMS and identify …

PTEN is a tumour suppressor gene, and its loss of function is frequently observed in both
heritable and sporadic cancers. It is involved in a great variety of biological processes …

Sarcomas represent a distinct group of rare malignant tumors with high heterogeneity.
Limited options with clinical efficacy for the metastatic or local advanced sarcoma existed …

Background Uterine leiomyosarcomas (uLMS) are aggressive tumours with poor prognosis
and limited treatment options. Although immune checkpoint blockade (ICB) has proven …

Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly
into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS) …

Objectives. Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease of
the gastrointestinal tract, and its prevalence is increasing worldwide. Fecal microbiota …

Simple Summary Uterine leiomyosarcoma is an aggressive and rare cancer that is difficult to
treat. There are a number of mutations that are common to uterine leiomyosarcoma that are …