The library of integrated network-based cellular signatures (LINCS) L1000 data set currently
comprises of over a million gene expression profiles of chemically perturbed human cell …

Data sets from recent large-scale projects can be integrated into one unified puzzle that can
provide new insights into how drugs and genetic perturbations applied to human cells are …

Gene expression data are accumulating exponentially in public repositories. Reanalysis and
integration of themed collections from these studies may provide new insights, but requires …

Large-scale heterozygous deletions are a hallmark of cancer genomes. The concomitant
loss of multiple genes creates vulnerabilities that are impossible to reveal through the study …

High‐throughput sequencing technologies are currently revolutionizing the field of biology
and medicine, yet bioinformatic challenges in analysing very large data sets have slowed …

Abstract Background RNA sequencing (RNA-Seq) has emerged as a powerful approach for
the detection of differential gene expression with both high-throughput and high resolution …

The Populus shoot undergoes primary growth (longitudinal growth) followed by secondary
growth (radial growth), which produces biomass that is an important source of energy …

Sex-biased genes are thought to drive phenotypic differences between males and females.
The recent availability of high-throughput gene expression data for many related species …

RNA editing plays a key posttranscriptional role in gene expression. Existing studies on
cytidine-to-uridine RNA editing in plants have focused on maize (Zea mays), rice (Oryza …

Pacific white shrimp (Litopenaeus vannamei) is an important cultural species worldwide.
However, Vibrio spp. infections have caused a great economic loss in Pacific white shrimp …