The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …

Post-translational modifications (PTMs) on intact histones play a major role in regulating
chromatin dynamics and influence biological processes such as DNA transcription …

Native mass spectrometry is a powerful tool for the analysis of noncovalent complexes.
When coupled with high-resolution ion mobility, this technique can be used to investigate …

Trapped ion mobility spectrometry (TIMS) when coupled with mass spectrometry (MS) offers
great advantages for the separation of isobaric, isomeric, and/or conformeric species. In the …

α-Synuclein is an intrinsically disordered protein that plays a critical role in the pathogenesis
of neurodegenerative disorders, such as Parkinson's disease. Proteomics studies of human …

The “Histone Code” is comprised of specific types and positions of post-translational
modifications (PTMs) which produce biological signals for gene regulation and have …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to native ion mobility
spectrometry mass spectrometry (IMS-MS) can provide complementary structural information …

With the recent improvements in ion mobility resolution, it is now possible to separate small
protomeric tautomers, called protomers. In larger molecules above 1000 Da such as …

Native top-down mass spectrometry is a powerful approach for characterizing proteoforms
and has recently been applied to provide similarly powerful insights into protein …

Glycans are biopolymers assembled from monosaccharides via the formation of glycosidic
bonds. They are found in nature either as free glycans (oligo-or polysaccharides) or in …