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Phosphoribosyl modification of poly-ubiquitin chains at the Legionella-containing vacuole prohibiting autophagy adaptor recognition
M Wan, ME Minelli, Q Zhao, S Marshall, H Yu… - Nature …, 2024 - nature.com
Ubiquitination is a posttranslational modification in eukaryotes that plays a significant role in
the infection of intracellular microbial pathogens, such as Legionella pneumophila. While …
the infection of intracellular microbial pathogens, such as Legionella pneumophila. While …
Robust Design of Effective Allosteric Activators for Rsp5 E3 ligase using the machine learning tool ProteinMPNN
HW Kao, WL Lu, MR Ho, YF Lin, YJ Hsieh… - ACS Synthetic …, 2023 - ACS Publications
We used the deep learning tool ProteinMPNN to redesign ubiquitin (Ub) as a specific and
functionally stimulating/enhancing binder of the Rsp5 E3 ligase. We generated 20 …
functionally stimulating/enhancing binder of the Rsp5 E3 ligase. We generated 20 …
Redox control of the deubiquitinating enzyme Ubp2 regulates translation during stress
Protein ubiquitination is essential to govern cells' ability to cope with harmful environments
by regulating many aspects of protein dynamics from synthesis to degradation. As important …
by regulating many aspects of protein dynamics from synthesis to degradation. As important …
Bacterial ligases reveal fundamental principles of polyubiquitin specificity
Summary Homologous to E6AP C terminus (HECT) E3 ubiquitin (Ub) ligases direct
substrates toward distinct cellular fates dictated by the specific form of monomeric or …
substrates toward distinct cellular fates dictated by the specific form of monomeric or …
Bacterial mimicry of eukaryotic HECT ubiquitin ligation
HECT E3 ubiquitin (Ub) ligases direct their modified substrates toward a range of cellular
fates dictated by the specific form of monomeric or polymeric Ub (polyUb) signal that is …
fates dictated by the specific form of monomeric or polymeric Ub (polyUb) signal that is …
[PDF][PDF] Strangers in a strange land: bacteria provide mechanistic insight into eukaryotic ubiquitination
TG Franklin - 2023 - digitalcollections.ohsu.edu
Post-translational regulation through attachment of the small protein modifier ubiquitin (Ub)
is a conserved and essential process among all eukaryotic life. Protein ubiquitination can …
is a conserved and essential process among all eukaryotic life. Protein ubiquitination can …