Crystallins in the eye: function and pathology
UP Andley - Progress in retinal and eye research, 2007 - Elsevier
Crystallins are the predominant structural proteins in the lens that are evolutionarily related
to stress proteins. They were first discovered outside the vertebrate eye lens by Bhat and …
to stress proteins. They were first discovered outside the vertebrate eye lens by Bhat and …
Signaling and gene regulatory networks in mammalian lens development
Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …
Eye organogenesis: a hierarchical view of ocular development
This chapter provides an overview of the early developmental origins of six ocular tissues:
the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of …
the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of …
Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis
JW Shin, M Min, F Larrieu-Lahargue… - Molecular biology of …, 2006 - Am Soc Cell Biol
Fibroblast growth factors play important roles in angiogenesis, but their functions in
lymphangiogenesis remain poorly understood. The homeodomain transcription factor Prox1 …
lymphangiogenesis remain poorly understood. The homeodomain transcription factor Prox1 …
KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming
A Hansen, S Henderson, D Lagos… - Genes & …, 2010 - genesdev.cshlp.org
Kaposi sarcoma herpesvirus (KSHV) induces transcriptional reprogramming of endothelial
cells. In particular, KSHV-infected lymphatic endothelial cells (LECs) show an up-regulation …
cells. In particular, KSHV-infected lymphatic endothelial cells (LECs) show an up-regulation …
Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development
J Sun, S Rockowitz, Q ** forebrain, Pax6 is expressed in ventricular zone precursor cells and …
[BOOK][B] Gene sharing and evolution: the diversity of protein functions
J Piatigorsky - 2007 - degruyter.com
This book explores gene sharing—a term originally coined to describe the observation that
structural proteins (called crystallins) responsible for the transparent and refractive …
structural proteins (called crystallins) responsible for the transparent and refractive …
Genetic and epigenetic mechanisms of gene regulation during lens development
Recent studies demonstrated a number of links between chromatin structure, gene
expression, extracellular signaling and cellular differentiation during lens development …
expression, extracellular signaling and cellular differentiation during lens development …
Mutation update of transcription factor genes FOXE3, HSF4, MAF, and PITX3 causing cataracts and other developmental ocular defects
Mutations in the transcription factor genes FOXE3, HSF4, MAF, and PITX3 cause congenital
lens defects including cataracts that may be accompanied by defects in other components of …
lens defects including cataracts that may be accompanied by defects in other components of …
Expression of Prox1 during mouse cochlear development
O Bermingham‐McDonogh, EC Oesterle… - Journal of …, 2006 - Wiley Online Library
We carried out an analysis of the expression of Prox1, a homeodomain transcription factor,
during mouse inner ear development with particular emphasis on the auditory system. Prox1 …
during mouse inner ear development with particular emphasis on the auditory system. Prox1 …