Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …

The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Oxidative stress is defined as an imbalance between production of free radicals and reactive
metabolites or [reactive oxygen species (ROS)] and their elimination by through protective …

Abstract Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …

Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
main cause of dementia. Common hallmarks of AD include the amyloid β-peptide (Aβ) …