Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines

T Nakamura, Y Sato, Y Yamada… - Advanced drug delivery …, 2022 - Elsevier
A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …

Revitalizing ancient mitochondria with nano‐strategies: mitochondria‐remedying nanodrugs concentrate on disease control

X Long, M Liu, Y Nan, Q Chen, Z **ao… - Advanced …, 2024 - Wiley Online Library
Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital
functions across diverse cellular processes. Dysfunctions within mitochondria serve as …

Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation

W Li, X Hu, S Wang, Z Jiao, T Sun, T Liu… - International Journal of …, 2020 - Elsevier
Astragalus polysaccharide (APS) has attracted growing interests in the field of anti-cancer by
direct killing effect and improving immune function. In this study, the structure and …

Programmed cell death in asthma: apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis

L Liu, L Zhou, LL Wang, PD Zheng… - Journal of …, 2023 - Taylor & Francis
Bronchial asthma is a complex heterogeneous airway disease, which has emerged as a
global health issue. A comprehensive understanding of the different molecular mechanisms …

Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment

J Qin, N Gong, Z Liao, S Zhang, P Timashev, S Huo… - Nanoscale, 2021 - pubs.rsc.org
Mitochondria play critical roles in the regulation of the proliferation and apoptosis of
cancerous cells. Nanosystems for targeted delivery of cargos to mitochondria for cancer …

Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

Mitochondrial targeted strategies and their application for cancer and other diseases treatment

Q Li, Y Huang - Journal of Pharmaceutical Investigation, 2020 - Springer
Background Known as the main site of ATP production and intrinsic apoptosis regulator,
mitochondria play vital roles in physiological functions and pathological progression …

Nanomedicines targeting respiratory injuries for pulmonary disease management

D Liu, M Long, L Gao, Y Chen, F Li… - Advanced Functional …, 2022 - Wiley Online Library
The respiratory system holds crucial importance in the biology of vertebrate animals. Injuries
of the respiratory system caused by viral infections (eg, by COVID‐19, MERS, and SARS) …

Tumor-responsive dynamic nanoassemblies for targeted imaging, therapy and microenvironment manipulation

LE Low, J Wu, J Lee, BT Tey, BH Goh, J Gao… - Journal of Controlled …, 2020 - Elsevier
The recent designs of dynamic nanoassemblies exploiting the tumor-targeting properties
have received increasing attention for tumor imaging and therapy due to their tumor-specific …

Targeted mitochondrial nanomaterials in biomedicine: Advances in therapeutic strategies and imaging modalities

Z Chen, L Chen, T dong Lyu, S Weng, Y **e, Y **… - Acta Biomaterialia, 2024 - Elsevier
Mitochondria, pivotal organelles crucial for energy generation, apoptosis regulation, and
cellular metabolism, have spurred remarkable advancements in targeted material …